Which combination is used with lifestyle modification in ages 12+?

• A. Phentermine / Topiramate
• B. Orlistat / Metformin
• C. Liraglutide / Sitagliptin
• D. Semaglutide / Bupropion

Answer: (A)

In adolescents 12 years and older, adding medication to lifestyle modification is an option when weight goals aren’t reached with lifestyle changes alone. The only pairing on the list that represents a true anti-obesity drug combination used with lifestyle modification in this age group is a phentermine combined with topiramate. Phentermine provides appetite suppression and topiramate helps reduce appetite and promote weight loss through multiple mechanisms, and together they’re used to enhance weight loss outcomes in suitable young patients when other measures haven’t worked.

The other options pair drugs that aren’t used together as a standard pediatric obesity regimen. Some are diabetes meds, some are single-agent obesity therapies, and some combinations aren’t established practice for youth. Medication choices always require careful clinical judgment and monitoring.