Of the following medications, which one is not approved for weight management because of limited efficacy?

• A. Orlistat
• B. Lisdexamfetamine
• C. Phentermine
• D. Liraglutide

Answer: (B)

Medications for weight management must show meaningful, durable weight loss and carry an approved indication for obesity. Lisdexamfetamine fits this pattern for ADHD and, in some cases, binge eating disorder, but it does not have an obesity-specific approval because the weight loss benefits are not robust enough to justify labeling for weight management. In contrast, other options have clear, labeled roles: one reduces fat absorption to aid weight loss, another is approved for short-term use in adults, and another (at appropriate doses) has demonstrated weight loss and is approved for obesity management in adults and in youths 12 and older. So the med not approved for weight management due to limited efficacy is lisdexamfetamine.