JPPT White Paper recommendations suggest dosing in children with overweight or obesity should be what?

• A. Weight-based dosing should be used for all children across weight categories
• B. Only for children under 40 kg
• C. Only for children over 40 kg
• D. Fixed dosing is preferred

Answer: (A)

The main idea is that dosing in children with overweight or obesity should be based on body weight across all weight categories. This approach helps keep drug exposure consistent as size changes, since obesity can alter how a drug distributes in the body and how it is cleared. Using a fixed amount for everyone can lead to too high exposure in smaller children or too low exposure in larger ones, risking safety or lack of efficacy. Therefore, weight-based dosing scales with the child’s size, providing a more reliable and safer way to achieve the intended therapeutic effect across the entire weight spectrum.