Choose the medication that is not approved for weight management because of low efficacy.

• A. Lisdexamfetamine
• B. Phentermine
• C. Orlistat
• D. Liraglutide

Answer: (A)

The idea here is that weight-management drugs are judged by how reliably they produce meaningful, durable weight loss and how acceptable their safety profiles are. Lisdexamfetamine, a stimulant, has not shown enough durable, clinically meaningful weight loss in studies to warrant approval for obesity treatment, and it carries risks such as abuse potential and cardiovascular stimulation. Those safety and efficacy concerns outweigh any appetite-suppressing effects, so it isn’t approved for weight management. In contrast, phentermine, orlistat, and liraglutide have demonstrated more substantial, sustained weight loss in trials and are approved for obesity management, which is why they fit as approved options while lisdexamfetamine does not.