A fixed (non-weight-based) dose tends to do which in obese patients?

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Multiple Choice

A fixed (non-weight-based) dose tends to do which in obese patients?

Explanation:
Giving the same fixed amount of a drug to people who differ greatly in weight means the mg per kg people receive becomes smaller as weight increases. In obesity, total body weight is much higher, so a fixed dose provides a lower mg/kg exposure, often resulting in subtherapeutic drug levels. That’s why a fixed, non-weight-based dose tends to under-dose obese patients: the amount of drug isn’t sufficient to achieve the needed plasma concentration across a larger body size.

Giving the same fixed amount of a drug to people who differ greatly in weight means the mg per kg people receive becomes smaller as weight increases. In obesity, total body weight is much higher, so a fixed dose provides a lower mg/kg exposure, often resulting in subtherapeutic drug levels. That’s why a fixed, non-weight-based dose tends to under-dose obese patients: the amount of drug isn’t sufficient to achieve the needed plasma concentration across a larger body size.

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